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Innate immunity Antigen recognition Web alert

โœ Scribed by DavidR Greaves

Book ID
104358824
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
78 KB
Volume
10
Category
Article
ISSN
0952-7915

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โœฆ Synopsis

Innate immunity

Innate (or nonadaptive) immune responses to pathogens are less specific but no less important than classical T-cell and B-cell responses to pathogens. The key cellular players in the innate immune system are the macrophages and neutrophils which are the professional phagocytes. Other cell types notable for their role in innate immunity are the large granular lymphocytes, which include natural killer cells. In addition to phagocytosis and complement fixation innate immunity relies on the secretion of antimicrobial proteins such as lysozyme and defensins. Genetic diseases which result in a defective innate immune response include chronic granulomatous disease (CGD) and leukocyte adhesion deficiency (LAD).

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