Antibody responses to the Wa human rotavirus (HRV) nonstructural protein NSP4, a viral enterotoxin, were evaluated in neonatal gnotobiotic (Gn) pigs. Gn pigs were inoculated orally with one dose of 10(5) fluorescent focus units (FFU) of virulent Wa HRV (HRV-V), to mimic natural infection, or with th
✦ LIBER ✦
Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model
✍ Scribed by Ana M. González; Marli S. P. Azevedo; Kwonil Jung; Anastasia Vlasova; Wei Zhang; Linda J. Saif
- Book ID
- 108782765
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 682 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0019-2805
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Rotavirus nonstructural protein NSP4 has recently been suggested to function as a viral enterotoxin and play a role in the pathophysiological mechanism whereby rotaviruses induce diarrhea. The ability of rotavirus NSP4 to stimulate a humoral immune response was examined in naturally infected childre