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Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte

✍ Scribed by Bao, Siqin; Miyoshi, Naoki; Okamoto, Ikuhiro; Jenuwein, Thomas; Heard, Edith; Azim Surani, M


Book ID
110032813
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
327 KB
Volume
6
Category
Article
ISSN
1469-221X

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## Abstract Summary: Genome‐wide epigenetic reprogramming by demethylation occurs in early mouse embryos and primordial germ cells. In early embryos many single‐copy sequences become demethylated both by active and passive demethylation, whereas imprinted gene methylation remains unaffected. In pri