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Initial slope technique to estimate first- and zero-order drug absorption rate constants

โœ Scribed by Jianguo Zhi


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
239 KB
Volume
77
Category
Article
ISSN
0022-3549

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A MODIFIED RESIDUAL METHOD TO ESTIMATE T
โœ XINGRONG LIU; KIM L. R. BROUWER; GARY M. POLLACK ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 521 KB

The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of residuals versus e 7Kt is linear for a zero-order absorption process,