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“Absorption rate constants” calculated according to the one-compartment open model with first-order absorption: Implications in in vivo-in vitro correlations

✍ Scribed by John G. Wagner


Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
193 KB
Volume
59
Category
Article
ISSN
0022-3549

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A MODIFIED RESIDUAL METHOD TO ESTIMATE T
✍ XINGRONG LIU; KIM L. R. BROUWER; GARY M. POLLACK 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of residuals versus e 7Kt is linear for a zero-order absorption process,