Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells
โ Scribed by Nicola C. Partridge; Anne Louise Opie; Rebecca T. Opie; T. John Martin
- Book ID
- 110555404
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 510 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1432-0827
No coin nor oath required. For personal study only.
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## Abstract Recombinant human granulocyteโmacrophage colonyโstimulating factor (rhGMโCSF) promotes the growth of a variety of hematopoietic and nonhematopoietic cells, both benign and malignant. There is now evidence that osteoblastโlike cells produce GMโCSF and their growth is stimulated by this c
## Abstract Parathyroid hormoneโrelated peptide (PTHrP) and parathyroid hormone (PTH) have similar biological effects in vitro that are mediated through the PTH receptor. PTH receptors have been demonstrated in the zone of provisional calcification and the hypertrophic zone of the cartilaginous gro
Parathyroid hormone (PTH) binds specifically to the hypertrophic region of growth plate cartilage [16]. This specific binding suggests a role for this hormone in chondrocyte maturation. Enzymatically isolated chick articular and growth plate chondrocytes grown in monolayer culture were used to assay