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Inhibitory effects of Ougi-keishi-gomotsu-to, a traditional herbal medicine, on lipid peroxidation and protein oxidative modification of mouse brain homogenate induced by copper

✍ Scribed by Shizuo Toda; YYoshiro Yase

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 39 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199905)13:3<251::aid-ptr428>3.0.co;2-o

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✦ Synopsis

Ougi-Keishi-gomotsu-to a traditional herbal medicine, is used clinically for patients with abnormal sensations and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification of brain homogenate induced by copper. Its effect was stronger than those of mannitol and a-tocopherol as free radical scavenger and antioxidant. These results demonstrated that Ougi-keishi-gomotsu-to has antioxidative effects on neuron injury derived from oxidative stress induced by metal.

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