Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells
β Scribed by Jung Soo Shin; Sang Sun Lee; Myung Koo Lee
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 18 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0253-6269
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## Abstract The effects of scoparone on dopamine biosynthesis and LβDOPAβinduced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100β200 ΞΌM showed a 128β136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased
The effects of dopamine and L-DOPA on survival were examined in differentiated PC12 cells. Addition of dopamine to the culture medium at 3-30 M prevented cell death induced by depletion of serum and nerve growth factor (NGF). At 100 M, dopamine induced cell death. The cell-protective effect of dopam