Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells
✍ Scribed by A. Östergren; N. G. Lindquist; E. B. Brittebo
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 448 KB
- Volume
- 114
- Category
- Article
- ISSN
- 1435-1463
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## Abstract The effects of scoparone on dopamine biosynthesis and L‐DOPA‐induced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100–200 μM showed a 128–136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased
The effects of dopamine and L-DOPA on survival were examined in differentiated PC12 cells. Addition of dopamine to the culture medium at 3-30 M prevented cell death induced by depletion of serum and nerve growth factor (NGF). At 100 M, dopamine induced cell death. The cell-protective effect of dopam