Inhibitory effects of lupeol on 3T3-L1 preadipocyte differentiation
โ Scribed by Keishi Hata; Kazuyuki Hiwatashi; Mizuho Itoh; Nao Suzuki; Takayuki Watanabe; Junichiro Takahashi; Hiroki Sasaki
- Book ID
- 108245859
- Publisher
- Elsevier
- Year
- 2008
- Tongue
- English
- Weight
- 437 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1874-3900
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Differentiation of 3T3-L1 preadipocytes, induced by methyl-isobutylxanthine (MIX), dexamethasone (DEX), and insulin, results in cells with the morphological and biochemical characteristics of adipocytes. Following incubation of 3T3-L1 cells with MIX, DEX, and insulin, poly(ADP-ribose) synthetase act
The active metabolite of vitamin D3, 1 a,25-dihydroxyvitamin D3 (1,25(OH),D,), inhibited morphologic and enzymatic expression during differentiation of preadipocyte to adipocyte. In the presence of -6.4-20 x M 1 ,25(OH)>Di, the triacylglycerol accumulation was only 50% of that of fully differentiate