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Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells

✍ Scribed by Thanh-Sang Vo; Chang-Suk Kong; Se-Kwon Kim


Book ID
108079997
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
732 KB
Volume
84
Category
Article
ISSN
0144-8617

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In rat basophilic leukemia cells (RBL-2H3), a tumor analogue of mast cells, the aggregation of IgE receptors initiates increase in the intracellular concentration of calcium ([Ca2+]i), monitored with the fluorescent Ca probe fura-2, and finally results in histamine secretion. In cell suspensions, ho