## Abstract Hydroxylated polymethoxyflavones (PMFs) are a class of novel flavonoid compounds mainly found in citrus plants. We studied the effects of three major 5‐hydroxy PMFs, namely: 5‐hydroxy‐6,7,8,3′,4′‐pentamethoxyflavone, 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone, and 5‐hydroxy‐6,7,8,4′‐tet
Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells
✍ Scribed by Alessandro Ottaiano; Antonella di Palma; Maria Napolitano; Carmen Pisano; Sandro Pignata; Fabiana Tatangelo; Gerardo Botti; Angela Maria Acquaviva; Giuseppe Castello; Paolo Antonio Ascierto; Rosario Vincenzo Iaffaioli; Stefania Scala
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 644 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0340-7004
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The authors thank Dr. Takeshi Okuda for helpful discussion, Ms. Yumiko Tamagawa for animal care, and Mr. Hidemasa Takafuji for technical assistance.
## Abstract **Scope:** Previously, we reported that 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone (5HHMF), a polymethoxyflavone found in citrus peels, potently inhibited the growth of multiple human colon cancer cells. Herein, we further investigated the anti‐cancer mechanisms of 5HHMF in human colon
In colorectal cancer, matrilysin (matrix metalloproteinase-7) is mainly produced by the tumor cells themselves and is thought to play an important role in tumor invasion and metastasis. In the study reported here, we examined the effects of matrilysin antisense phosphorothioate oligonucleotides on b