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Inhibitory effect of gomisi on reductive metabolism of halothane

✍ Scribed by Ni Jiaxiang; Kohyu Fujii; Nobuyoshi Sato; Osafumi Yuge

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 353 KB
Volume: 13
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550130604

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of Gomisi (dried ripe fruit of schizandra chinensis) on chlorodifluoroethylene (CDE) and chlorotrifluoroethane (CTE) formation was investigated. The incubation mixtures for the measurement of reductive metabolites of halothane consisted of liver microsomal suspensions, 3 mM NADPH, extract solution of Gomisi and halothane in 0.1 M potassium phosphate buffer (pH 7.4). The production of CDE and CTE was inhibited by Gomisi in a dose‐dependent way. The production were reduced to half in the presence of 0.5% Gomisi extract in the reaction mixture. The results suggest that Gomisi can inhibit the reductive metabolism of halothane in vitro; thus it may protect against halothane‐induced hepatitis.

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