✦ LIBER ✦

Effect of halothane anesthesia on extravascular mobilization of neutrophils

✍ Scribed by David L. Bruce

Publisher: John Wiley and Sons
Year: 1966
Tongue: English
Weight: 252 KB
Volume: 68
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040680111

No coin nor oath required. For personal study only.

✦ Synopsis

The ability of neutrophil leukocytes to extravasate into the peritoneal cavity in response to a n intraperitoneal injection of bacterial endotoxin was studied i n mice. The normal response of a marked accumulation of intrapcritoneal neutrophils was comrletely abolished by halothane anesthesia. It was further shown that such abolition depended uFon the presence of halothane during the time the extravasation would normally be occurring. The evidence points toward a n effect on either the leukocyte or the vessel rather than a non-specific "stress" effect. It is suggested that the effect is on the neutrophil, rendcring it less deformable and, hence, less able to undergo trans-vascular diapedesis.

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