## Abstract Sepsis is a systemic response to infection in which toxins, such as bacterial lipopolysaccharide (LPS), stimulate the production of inflammatory mediators like the cytokine tumor necrosis factor alpha (TNFβΞ±). Previous studies from our laboratory have revealed that LPS inhibits the inte
Inhibitory effect of acetylcholine on muscular tonus of the small intestine of a lizard
β Scribed by Wacyk, Jurij ;Guerrero, Sergio ;Morello, Antonio
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 433 KB
- Volume
- 230
- Category
- Article
- ISSN
- 0022-104X
No coin nor oath required. For personal study only.
β¦ Synopsis
The present report concerns the effects of cholinergic agonists on the isometric tension of "in vitro" preparations of the esophagus and distal part of the small intestine of the lizard Liolaemus grauenhorsti.
Acetylcholine (Ach) and carbachol elicited a dose-related increase of isometric tension in the esophagus, whereas the small intestine was slowly relaxed by these drugs. Eserine induced a synergistic action on the cholinergic responses of both organs, and atropine completely antagonized the respective effects.
The esophagus and the intestine showed different thresholds for the cholinergic evoked responses, the former being about 30 times more sensitive than the intestine. Assessment of cholinesterase activity revealed that Ach is hydrolyzed at a significant lesser speed in the intestine than in the esophagus.
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## Abstract The acetylcholine (ACh) responses of anterior aorta muscle cells of Aplysia kurodai were studied by intracellular recording and ACh iontophoresis. Three different types of membrane potential change were observed in response to ACh pulses: a rapid Na^+^βmediated depolarizing response, a