Inhibitory effect of 4-methylpyrazole on antipyrine clearance in rats
β Scribed by H.H. Chow; A. Hutchaleelaha; M. Mayersohn
- Book ID
- 118345443
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 347 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0024-3205
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π SIMILAR VOLUMES
A group of 15 rats received two intravenous bolus doses of antipyrine (15 mg/kg) separated by a 57 hour infusion (with bolus dose) of phenobarbital. Phenobarbital bolus doses and infusion rates were based on a preliminary pharmacokinetic study (7 rats) and were varied to achieve a broad range of ste
## Methods: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis. Results: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs