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Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease

✍ Scribed by K. Grønbaek; H. Friis; M. Feldman; J. Sonne; P. B. Andreasen

Publisher
Springer
Year
1996
Tongue
English
Weight
296 KB
Volume
49
Category
Article
ISSN
0031-6970

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✦ Synopsis

Methods:

The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis. Results: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9ml.min 1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs = 0.76) as well as after zinc supplementation (rs = 0.72).

Conclusion:

No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease.

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