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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

✍ Scribed by McInnes, Campbell; Mazumdar, Aveek; Mezna, Mokdad; Meades, Christopher; Midgley, Carol; Scaerou, Fred; Carpenter, Lee; Mackenzie, Mairi; Taylor, Paul; Walkinshaw, Malcolm

Book ID
109914114
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
536 KB
Volume
2
Category
Article
ISSN
1552-4450

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## Abstract **Playing polo**: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 func