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Inhibitors of Plasmin that Extend into Both the S and S‘ Binding Sites: Cooperative Interactions between S1 and S2

✍ Scribed by Abato, Paul; Yuen, Courtney M.; Cubanski, Jeanne Y.; Seto, Christopher T.


Book ID
118040967
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
135 KB
Volume
67
Category
Article
ISSN
0022-3263

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A number of epoxysuccinyl amino acid benzyl esters (HO-Eps-AA-OBzl, 1) in which the amino acid (AA) had been systematically varied were tested as inhibitors of cathepsins \(\mathrm{L}\) and S. These E-64 analogs were designed to investigate whether selectivity for cathepsin \(\mathbf{L}\) or catheps