## Background: Neuroblastoma is a common childhood cancer with a poor overall prognosis. retinoic acids (ras) have been studied as a potential therapy, showing promise in recurrent disease. the histone deacetylase inhibitor (hdaci) m-carboxycinnamic acid bishydroxamide (cbha) is another potential t
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
✍ Scribed by Johnsen, J I; Segerström, L; Orrego, A; Elfman, L; Henriksson, M; Kågedal, B; Eksborg, S; Sveinbjörnsson, B; Kogner, P
- Book ID
- 110072919
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 611 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Activation of the PI3K/Akt signaling pathway is correlated with poor prognosis in neuroblastoma, the most common and deadly extracranial tumor of childhood. In this study, we show that the small‐molecule inhibitors of phosphoinositide‐dependent protein kinase‐1 (PDK1) OSU03012 and the d