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Inhibitors of intracellular phospholipase A2 activity: their neurochemical effects and therapeutical importance for neurological disorders

โœ Scribed by Akhlaq A Farooqui; Monica L Litsky; Tahira Farooqui; Lloyd A Horrocks


Book ID
117502820
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
281 KB
Volume
49
Category
Article
ISSN
0361-9230

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The role of aspartic acid49 (Asp-49) in the active site of porcine pancreatic phospholipase A2 was studied by recombinant DNA techniques: two mutant proteins were constructed containing either glutamic acid (Glu) or lysine (Lys) at position 49. Enzymatic characterization indicated that the presence