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Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders

โœ Scribed by Farooqui, A. A.


Book ID
126928127
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2006
Tongue
English
Weight
563 KB
Volume
58
Category
Article
ISSN
0031-6997

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The role of aspartic acid49 (Asp-49) in the active site of porcine pancreatic phospholipase A2 was studied by recombinant DNA techniques: two mutant proteins were constructed containing either glutamic acid (Glu) or lysine (Lys) at position 49. Enzymatic characterization indicated that the presence