𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibitors of Anthrax Lethal Factor.

✍ Scribed by Brandon D. Gaddis; Larisa V. Avramova; Jean Chmielewski


Book ID
102015742
Publisher
John Wiley and Sons
Year
2007
Weight
14 KB
Volume
38
Category
Article
ISSN
0931-7597

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Antidotes to anthrax lethal factor intox
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Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.