✦ LIBER ✦
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy
✍ Scribed by Guan-Sheng Jiao; Seongjin Kim; Mahtab Moayeri; Lynne Cregar-Hernandez; Linda McKasson; Stephen A. Margosiak; Stephen H. Leppla; Alan T. Johnson
- Book ID
- 104004783
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 296 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
✦ Synopsis
Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.