✍ Scribed by Jonathan R. Heal; Gareth W. Roberts; Gary Christie; Andrew D. Miller
No coin nor oath required. For personal study only.
Complementary peptides are coded for by the nucleotide sequence (read 5' 33') of the complementary strand of DNA. By reading the sequence of complementary DNA in the 3' 35' direction, alternative complementary peptides may be derived. We describe the derivation, testing and analysis of six complementary peptides designed against b-amyloid peptide 1-40 (Ab 1-40 ). Data is presented to show that one peptide, designated 3' 35' bCP 1-15 , binds specifically to Ab 1-40 , and inhibits both fibrilisation and neurotoxicity in vitro. This suggests that complementary peptides could be useful leads for drug discovery, especially where diseases of protein misfolding are concerned.
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