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Inhibition of β-adrenoceptor agonist relaxation of airway smooth muscle by Ca2+-activated K+ channel blockers

✍ Scribed by Jiao-Cheng Huang; Maria L. Garcia; John P. Reuben; Gregory J. Kacsorowski


Book ID
115888893
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
653 KB
Volume
235
Category
Article
ISSN
0014-2999

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Ca2+-activated K+channels in airway smoo
✍ Klaus Groschner; Shai D. Silberberg; Craig H. Gelband; Cornelis Breemen 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 613 KB

Large-conductance Ca2+-activated K + channels were studied in membranes of cultured rabbit airway smooth muscle cells, using the patch-clamp technique. In cell-attached recordings, channel openings were rare and occurred only at very positive potentials. Bradykinin (10 gM), an agonist which releases