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Inhibition of α5 integrin decreases PI3K activation and cell adhesion of human colon cancers

✍ Scribed by Carlos A. Murillo; Piotr G. Rychahou; B.Mark Evers


Book ID
113919772
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
310 KB
Volume
136
Category
Article
ISSN
0039-6060

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Phosphatidylinositol-3-kinases (PI3Ks) exert a variety of signaling functions in eukaryotes. We suppressed the PI3K regulatory subunit p85a using a small interfering RNA (Pik3r1 siRNA) and examined the effects on embryoid body (EB) development in hanging drop culture. We observed a 150% increase in