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Downregulation of the PI3k/Akt pathway leads to decreased invasion of the human colon cancer cells

✍ Scribed by Piotr G. Rychahou; Carlos Murillo; B.Mark Evers


Book ID
113675926
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
54 KB
Volume
199
Category
Article
ISSN
1072-7515

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of