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Inhibition of tumor growth by peptide specific cytotoxic T lymphocytes in a three-dimensional collagen matrix

✍ Scribed by Wei-Zen Wei; Bonnie Miller; Richard M. Gutierrez


Book ID
114051658
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
705 KB
Volume
200
Category
Article
ISSN
0022-1759

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Melanoma-specific T-cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T-cells to inhibit growth of human melanoma xenografts by using a Winn assay. Nude mice receiving specific CTLs (n = 1