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Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

✍ Scribed by Kuba, Keiji; Shimura, Hideo; Tanaka, Masao; Nakamura, Toshikazu; Date, Kazuhiko; Matsumoto, Kunio

Book ID
110061700
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
694 KB
Volume
17
Category
Article
ISSN
0950-9232

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Inhibition of Met/HGF receptor and angio
Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma
✍ Yoshinori Suzuki; Katsuya Sakai; Junko Ueki; Qing Xu; Takahiro Nakamura; Hideaki πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 707 KB

## Abstract NK4 exhibits two distinct biological actions: antagonistic inhibition of hepatocyte growth factor (HGF) through binding to the Met/HGF receptor, and antiangiogenic action through binding to perlecan. Here, the anti‐tumor effect of NK4 on malignant pleural mesothelioma was investigated.