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Inhibition of transcription by platinated triplex-forming oligonucleotides

✍ Scribed by Mindy K. Graham, Paul S. Miller

Book ID: 120921592
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 642 KB
Volume: 17
Category: Article
ISSN: 1432-1327
DOI: 10.1007/s00775-012-0933-9

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## Abstract Triplex‐forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence‐specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA‐reactive agents to specific locations in the genome, or can induce target