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Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides

✍ Scribed by Noonberg, Sarah B.; Scott, Gary K.; Hunt, C.Anthony; Hogan, Michael E.; Benz, Christopher C.


Book ID
122813892
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
523 KB
Volume
149
Category
Article
ISSN
0378-1119

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Overexpression of the HER2/Neu receptor is correlated to a poor prognosis in tumor patients and leads to stimulation of mitogen-activated protein kinase (MAPK) signaling pathways, which in turn activate transcription factors, such as the ETS protein ER81. Here, we have analyzed whether, on the other