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Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo: evidence for a structure-activity relationship

✍ Scribed by D.J. Back; J.F. Tjia


Book ID
117958255
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
747 KB
Volume
85
Category
Article
ISSN
0007-1188

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Evidence for a Structure-Function Relati
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Kinetic parameters for the metal ion activation of calcineurin at 30Β°C were found to be correlated to the formation constants (log K 1 ) of the activating metal ions (Mn 2+ , Co 2+ , Ni 2+ , Zn 2+ , and Mg 2+ ) with the substrate para-nitrophenyl phosphate (pNPP). Metal ion activation measured by k