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Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism

✍ Scribed by Takaki Tokairin; Takashi Fukasawa; Norio Yasui-Furukori; Toshiaki Aoshima; Akihito Suzuki; Yoshimasa Inoue; Tomonori Tateishi; Koichi Otani


Book ID
108640365
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
105 KB
Volume
60
Category
Article
ISSN
0306-5251

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In Vitro/in Vivo scaling of alprazolam m
✍ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 243 KB πŸ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a