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Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5

✍ Scribed by Manuela Frese-Schaper; Julian A. Schardt; Toshiyuki Sakai; Giovanni L. Carboni; Ralph A. Schmid; Steffen Frese


Book ID
113622019
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
551 KB
Volume
584
Category
Article
ISSN
0014-5793

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## Abstract This article shows that HepG2, Hep3B, and SK‐Hep1 cells, three lines of human hepatocellular carcinoma (HCC) cells, are resistant to apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL). Parthenolide, a sesquiterpene lactone found in European feverfew, ha