482 Tumor Suppressor XAF1 Reverses TRAIL-Resistance in Hepatocellular Carcinoma Cells Through Upregulation of Death Receptor 4 and 5

Ionizing radiation enhances tumor necros

Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells

✍ Takeshi Hori; Takashi Kondo; Masahiko Kanamori; Yoshiaki Tabuchi; Ryohei Ogawa; 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 228 KB 👁 1 views

## Abstract Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma (OS), satisfactory results are still difficult to achieve. Novel therapeutic modalities need to be developed for osteosarcoma treatment. The combined effects of tumor necrosis factor‐related apoptosis‐indu