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Inhibition of thymidylate synthase by the diastereoisomers of leucovorin

โœ Scribed by Pauline P. Lee; Richard L. Schilsky


Book ID
105645907
Publisher
Springer
Year
1990
Tongue
English
Weight
497 KB
Volume
26
Category
Article
ISSN
0344-5704

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Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed