𝔖 Bobbio Scriptorium
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Inhibition of the Self-cleavage Reaction of the Human Hepatitis Delta Virus Ribozyme by Antibiotics

✍ Scribed by Jeff Rogers; Alex H. Chang; Uwe von Ahsen; Renée Schroeder; Julian Davies

Book ID
115627426
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
813 KB
Volume
259
Category
Article
ISSN
0022-2836

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Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme
✍ Jana Sefcikova; Maryna V. Krasovska; Nad'a Špačková; Jiří Šponer; Nils G. Walter 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 770 KB

## Abstract The self‐cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal