Inhibition of the replication of hepatitis B virus in vitro by a novel 2,6-diaminopurine analog, β-LPA
✍ Scribed by Xing-Xing He; Ting Chen; Ju-Sheng Lin; Ying Chang; Bai-Xin Ye
- Book ID
- 116296442
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 458 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The carbocyclic analog of deoxyguanosine inhibits hepatitis B virus replication by greater than 95% in the hepatitis B vim-producing cell line (2.2.15) as monitored by decreases of secreted hepatitis B virus DNA, hepatitis B virus polymerase activity and intracellular episomal hepatitis B virus DNA.
## Abstract Forty antiviral compounds were screened for inhibitory effect on hepatitis A virus (HAV) antigen expression in the human hepatoma cell line PLC/PRF/5. Ribavirin, amantadine, glycyrrhizin, and pyrazofurin were selected in this screening test and were studied further. The selectivity indi