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Inhibition of the passive diffusion of cholic acid by the Ilex paraguariensis St. Hil. saponins

✍ Scribed by Fernando Ferreira; Alvaro Vázquez; Carlos Güntner; Patrick Moyna

Book ID: 101287410
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 88 KB
Volume: 11
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199702)11:1<79::aid-ptr34>3.0.co;2-r

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✦ Synopsis

The Ilex paraguariensis St. Hil. (yerba mate) saponins effectively inhibit the passive diffusion of cholic acid through dialysis membranes. The formation of large macromolecular mixed micelles between cholic acid and yerba mate saponins could explain this effect. The observed inhibition of the passive diffusion of cholic acid used as a model of bile acids, could have an antihypercholesterolaemic effect in vivo due to an increased sterols excretion.

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