Inhibition of the mixed lymphocyte reaction by T cell vaccination

✍ Scribed by Ansgar W. Lohse; Eitan Mor; Tamara Reshef; Karl-Hermann Meyer Zum; Büschenfelde; Irun R. Cohen

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 432 KB
• Volume: 20
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830201126

✦ Synopsis

Inhibition of the mixed lymphocyte reaction by T cell vaccination*

Immunization with attenuated activated autoreactive T cell lines and clones induces a response in syngeneic animals which can induce protection or recovery from autoimmune disease. This process has been termed T cell vaccination. The aim of the present study was to investigate the effect of immunization with MHC-reactive T cells on the mixed lymphocyte reaction (MLR). By injecting attenuated activated Tcells primed for an alloantigen, we markedly reduced the MLR in both rats and mice. This depression appeared to be mediated by active suppression; lymphoid cells from Tcell-vaccinated animals suppressed the MLR responsiveness of Tcells from naive animals. Suppression of the MLR was not restricted to the major histocompatibility complex (MHC) alleles used to prime the animals from which theTcell vaccines were prepared; the MLR to other MHC allelic stimulator cells was also suppressed. This MHC-unrestricted suppression could not be attributed to an anti-ergotypic response to non-MHC-linked activation markers on Tcells; an anti-ergotypic response augmented rather than suppressed the MLR. We herein propose that T cell vaccination might influence the MLR by suppressing the responses of diverse Tcells which bear shared Tcell receptor idiotypes.