Inhibition of autologous mixed lymphocyte reaction by aggregated IgG molecules

✍ Scribed by Dieter Kabelitz; Giorgio Walter Canonica; Olof Sjöberg; Lars Klareskog; Hans Wigzell

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 533 KB
• Volume: 12
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830120812

✦ Synopsis

Inhibition of autologous mixed lymphocyte reaction by aggregated IgG molecules*

Human autologous and allogeneic mixed lymphocyte reactions (MLR) were studied using various T cell subsets as responding cells. T cells expressing Fcy receptor for IgG (TG) were weak responder while T cells with Fcp receptor and T cells lacking Fc receptor responded vigorously in both types of MLR. Percoll-separated T cells of low density (TL) enriched for T G cells were, however, excellent responders in autologous MLR, whereas T cells of high density (TH) were the major responders in allogeneic MLR. Continuous presence of or short-term pulse with aggregated IgG significantly reduced the autologous MLR of unfractionated T and T L cells while largely sparing proliferation in allogeneic MLR. These findings are discussed with respect to diminished autologous MLR reactivity in certain autoimmune diseases.