The effect of the cationic lipophilic phosphonium salt tetraphenylphosphonium chloride (TPP) on a human malignant breast cell line, DU4475, was monitored with proton nuclear magnetic resonance (IH MRS). TPP caused a dose-and timedependent increase in resonances arising from MR-visible lipid as measu
Inhibition of tetraphenylphosphonium-induced NMR-visible lipid accumulation in human breast cells by chlorpromazine
β Scribed by Nalayini Sathasivam; Susan Brammah; Lesley C Wright; Edward J Delikatny
- Book ID
- 117772339
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 982 KB
- Volume
- 1633
- Category
- Article
- ISSN
- 1388-1981
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π SIMILAR VOLUMES
Proton magnetic resonance spectroscopy ( 1 H MRS) and DNA flow cytometry were used to monitor the effects of the cationic lipophilic phosphonium salt and potential antineoplastic agent tetraphenylphosphonium chloride (TPP) on the transformed human breast cell line HBL-100. TPP treatment for 48 hr wa
Cationic lipophilic phosphonium salts (CLPS) selectively accumulate in the mitochondria of neoplastic cells and inhibit mitochondrial function. The effects of the CLPS p-(triphenylphosphoniummethyl) benzaldehyde chloride (drug A), and [4-(hydrazinocarboxy)-1-butyl] tris-(4-dimethylaminophenyl) phosp