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Inhibition of Telomerase with hTERT Antisense Increases Susceptibility of Leukemic Cells to CDDP-induced Apoptosis

✍ Scribed by Yuan Zhang; Dongmei HE


Publisher
Springer
Year
2004
Tongue
English
Weight
301 KB
Volume
3
Category
Article
ISSN
1610-1979

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of