Inhibition of T-Cell Acute Lymphoblastic Leukemia Proliferation In Vivo by Re-expression of the p16INK4a Tumor Suppressor Gene
β Scribed by Schoppmeyer, Konrad; Norris, Paula S.; Haas, Martin
- Book ID
- 122300226
- Publisher
- Neoplasia Press
- Year
- 1999
- Tongue
- English
- Weight
- 335 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1522-8002
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## Abstract Gene amplification is a relatively rare event in hematologic malignancies. The __ABL__ gene on chromosome band 9q34 is a protoβoncogene and is the wellβknown translocation partner of the __BCR__ gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leuk
Immunohistochemistry was used to analyze samples of 40 newly diagnosed childhood acute lymphoblastic leukemias (ALL) for their expression of cyclins (D1, E, A), cyclindependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16 INK4A ), in order to discover whether or not the expression of th