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Inhibition of succinate dehydrogenase by nitroacetate and by the toxic antibiotic nitraminoacetate

✍ Scribed by Theodore A. Alston; Steven P. Seitz; David J.T. Porter; Harold J. Bright

Book ID
119406801
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
309 KB
Volume
97
Category
Article
ISSN
0006-291X

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Brain succinate dehydrogenase (SDH) activity was inhibited by in vitro hexachlorophene (HCP) with a half inhibitory concentration (IC 50 ) of 0.65 ‫‬ 10 ‫3‬ M. The HCP exerted noncompetitive inhibition at 0.5 mM (Ο½IC 50 ), uncompetitive inhibition at 0.65 mM (IC 50 ), and mixed-type inhibition at 0.