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Inhibition of succinate dehydrogenase and β-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats

✍ Scribed by J. C. Dutra; C. S. Dutra-Filho; S. E. C. Cardozo; C. M. D. Wannmacher; J. J. F. Sarkis; M. Wajner

Publisher
Springer
Year
1993
Tongue
English
Weight
374 KB
Volume
16
Category
Article
ISSN
0141-8955

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✍ V. Lokanatha; P. Sailaja; W. Rajendra 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB 👁 2 views

Brain succinate dehydrogenase (SDH) activity was inhibited by in vitro hexachlorophene (HCP) with a half inhibitory concentration (IC 50 ) of 0.65 ‫‬ 10 ‫3‬ M. The HCP exerted noncompetitive inhibition at 0.5 mM (ϽIC 50 ), uncompetitive inhibition at 0.65 mM (IC 50 ), and mixed-type inhibition at 0.