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Inhibition of steroid 17α-hydroxylase and C17,20-lyase in the human testis by epitestosterone

✍ Scribed by Bičíková, Marie; Hampl, R.; Hill, M.; Stárka, L.


Book ID
123283214
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
221 KB
Volume
46
Category
Article
ISSN
0960-0760

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In the search for potent inhibitors of P450 17, the key enzyme of androgen biosynthesis, the 20,21-aziridinyl- and 20-aminopregnene steroids 1-11 were synthesized and tested toward rat testicular P450 17. Only the aziridinyl-substituted pregnenolones (1 and 2) and progesterones (3 and 4), respective