Epigenetic regulation of signal transduc
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Sampa Ghoshal (Gupta); Heinz Baumann; Meir Wetzler
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Article
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2008
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Elsevier Science
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English
β 350 KB
We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic prot