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Inhibition of Signal Transducer and Activator Transcription Factor 3 in Rats with Acute Hepatic Failure

✍ Scribed by Yukio Kamohara; Nozomu Sugiyama; Toru Mizuguchi; Daniel Inderbitzin; Helene Lilja; Yvette Middleton; Toomas Neuman; Achilles A. Demetriou; Jacek Rozga


Book ID
115585966
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
180 KB
Volume
273
Category
Article
ISSN
0006-291X

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We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic prot