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Inhibition of Retinoblastoma Tumor Suppressor Activity by RNA Interference in Lung Cancer Lines

✍ Scribed by Michael F. Reed; William A. Zagorski; John A. Howington; Jack T. Zilfou; Erik S. Knudsen

Book ID
116261878
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
335 KB
Volume
82
Category
Article
ISSN
0003-4975

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## Abstract High‐risk human papilloma virus (HPV) encodes two oncoproteins, E6 and E7, which are vital to viral replication and contribute to the development of cervical cancer. HPV16 E7 can target over 20 cellular proteins, but is best known for inactivating the retinoblastoma (RB) tumor suppresso